Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells
نویسندگان
چکیده
منابع مشابه
Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy.
In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin secretion (GSIS) per cell. Mechanisms have been proposed for the increased β cell mass, but not for the increased GSIS. Because serotonin production increases dramatically during pregnancy, we tested whether flux through the ionotropic 5-HT3 ...
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OBJECTIVE Interleukin-6 (IL-6) has a significant impact on glucose metabolism. However, the effects of IL-6 on insulin secretion from pancreatic β-cells are controversial. Therefore, we analyzed IL-6 effects on pancreatic β-cell functions both in vivo and in vitro. RESEARCH DESIGN AND METHODS First, to examine the effects of IL-6 on in vivo insulin secretion, we expressed IL-6 in the livers o...
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From the 1 Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan; the 2 Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan; and the 3 Section on Molecular Genetics of Immunity, Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institute...
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When glucose is raised from a basal to stimulating level, the pancreatic islets respond with a typical biphasic insulin secretion pattern. Moreover, the pancreas is able to recognize the rate of change of the glucose concentration. We present a relatively simple model of insulin secretion from pancreatic beta-cells, yet founded on solid physiological grounds and capable of reproducing a series ...
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The major goal in the treatment of type 2 diabetes mellitus is to control the hyperglycaemia characteristic of the disease. However, treatment with common therapies such as insulin or insulinotrophic sulphonylureas (SU), while effective in reducing hyperglycaemia, may impose a greater risk of hypoglycaemia, as neither therapy is self-regulated by ambient blood glucose concentrations. Hypoglycae...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2018
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.201812177